Kalexsyn formed in 2003 following the closure of Discovery Research operations at Pharmacia in Kalamazoo. Kalexsyn's co-founders, Dr. Robert Gadwood and David Zimmermann had worked with numerous CROs worldwide while at Pharmacia. Based on their client experiences they identified three clear areas that CROs often failed to deliver to their clients:

• True medicinal chemistry experience, not synthetic chemists that have made a biologically active molecule
• Scientists that have the experience to solve complex synthetic problems
• The ability to effectively communicate and collaborate with a pharma partner

The scientists at Kalexsyn are extremely experienced in practicing the art of medicinal chemistry.